The primary conflict that Thatcher had was the pro-European movement. The overwhelming majority of her own government wanted to go into the Euro. She stood her ground and because of her, she saved Britain from the Euro.
“We have not successfully rolled back the frontiers of the state in Britain, only to see them re-imposed at a European level with a European superstate exercising a new dominance from Brussels.” — Thatcher’s seminal Bruges address on Europe in September 1988.